The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A . 2012;109(17):6662–6667. View this article via: PubMed CrossRef Google Scholar

2021-03-02

Polymorphisms in the human inhibitory signal-regulatory protein alpha do not affect binding to its ligand CD47. SIRPA plays a protective role in cardiac hypertrophy through negative regulation of the Toll-like receptor 4/nuclear factor-kappaB pathway. The Targeting the CD47-SIRPA Axis in Oncology: Analytical Tool is continuously updated according to twelve of the world's most influential meetings in oncology (AACR, ASCO, ASGCT, ASH, CMIT, EHA SIRPα recognizes CD47, an anti-phagocytic signal that distinguishes live cells from dying cells. CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or cleavage of the receptor, or interaction with surfactant proteins. CD47 or SIRPa might thus mediate unidirectional signalling in the hematopoietic or immune systems. For instance, the binding of CD47 on RBCs (in which minimal expression of SIRPa exists) to SIRPa of macrophages regulates phagocytosis by macro-phages in a unidirectional manner (see later).

Cd47 sirpa

SIRPα is a transmembrane protein that contains three Ig. Open in new tabDownload slide. The CD47– CD47 binding to SIRP-alpha delivers a "Do Not Eat Me" signal to macrophages. In the case of a tumor, this signaling aids in tumor evasion of the immune system. Huajun Yang, Zhongliang Li, Beibei Tang, Phillip Wang, Qinyun Ma, Frank Xing, and Qian Shi CrownBio 2018. Poster 4556: Disrupting the CD47-SIRPa Sep 1, 2020 Similar to cancer cells, all immune cells can upregulate their CD47 surface expression during infection. The CD47-SIRPa interaction induces an The CD47|SIRPα Summit Goes Online for 2020. Targeted Cancer R&D has been rocked by Covid-19 but as an industry, we cannot afford to put things on hold.

Actively or passively take part in this session. The CD47/SIRPα Summit includes an extended break in the middle to give you ample time for lunch and another chance to catch-up on the day job. Or if you have time, you can use this break for 1-2-1 meetings or open networking.

CD47 acts as a “don’t eat me” signal that protects cells from phagocytosis by binding and activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro-engulfment “eat me” signals, including immunoglobulin G (IgG), complement, and calreticulin, on distinct target cells.

sirpα；cd47与受体的结合影响细胞黏附、迁移、炎症调节及吞噬功能。当红细胞缺失cd47时，能够被脾巨噬细胞迅速清除，因而，cd47作为一个“自我识别”的标志首次被发现。cd47与sirpα形成的信号通路及其作用如图1（英文原文图1）所示。

[6] 2020-05-19 · The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A . 2012;109(17):6662–6667.

Through its IgV-like domains, SIRPA interacts with its ligand CD47, which is ubiquitously expressed [22,23]. The binding of cell-surface CD47 with SIRPA on The CD47-SIRPa interaction induces an inhibitory effect on macrophages and dendritic cells (dendritic cells) while CD47-thrombospondin-signaling inhibits T cells. Creative Biolabs provides CD47 & SIRPA engineered antibodies such as therapeutic antibodies, nanobodies, bispecific antibodies and intrabodies. We also provide antibody / peptide libraries, Biosimilar cell lines, Chimeric antigen receptor (CAR) products, antibody-drug conjugates (ADCs) CD47 binding to SIRP-alpha delivers a "Do Not Eat Me" signal to macrophages. In the case of a tumor, this signaling aids in tumor evasion of the immune system. Huajun Yang, Zhongliang Li, Beibei Tang, Phillip Wang, Qinyun Ma, Frank Xing, and Qian Shi CrownBio 2018.
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In vitro, blockade of CD47 signaling using targeted monoclonal antibodies enabled macrophage phagocytosis of tumor cells that were otherwise protected. CD47 is well known to act as a ‘don’t eat me’ signal, interact with SIRPα on macrophages to deliver negative regulatory signals, and thus prevent phagocytic removal of the cells by the immune system.4 Previous studies have shown that upregulation of CD47 on hematopoietic stem cells and progenitor cells could act as a self-protective strategy against phagocytosis to avoid additional 2021-03-02 · CD47/SIRP-alpha interactions are implicated in the pathogenesis of DC-driven allergic airway inflammation.

The CD47/SIRPa Summit has been completely re-engineered to deliver the best networking experience together with exciting new learning opportunities.
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2019-12-04 · Willingham SB, Volkmer J-P, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012;109(17):6662–7. CAS PubMed PubMed Central Google Scholar 12.

Together, the results demonstrate that disruption of the SIRPα–CD47 immune checkpoint may augment NK cell antitumor responses and that elevated expression of CD47 may prevent NK cell–mediated killing of allogeneic and xenogeneic tissues. SIRPa–CD47 blockade, and highlight key issues for future investigations.

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Apr 2, 2021 Cd47 expressed on tumor cells and tumor stem cells has been identified as a Targeting the cd47 sirpa axis is emerging as one of the most

Silencing CD47 gene in Treg cells impaired the ability of Treg cells to protect dopaminergic neurons against MPP+ toxicity. The CD47-SIRPα mechanism was first reported by Oldenborg et al. , who had demonstrated in red blood cell (RBC) transfusion experiments that WT mice rapidly eliminate syngeneic Cd47-null (Cd47 −) RBCs through erythrophagocytosis in the spleen and that the lack of tyrosine phosphorylation in SIRPα ITIMs was associated with this macrophage aggressiveness. This protein is CD47 (Integrin-Associated Protein/IAP), which is recognized by the inhibitory receptor SIRPa (SHPS-1/BIT/P84) on Mf or DC. The interaction of these two proteins does not only regulate phagocytosis in Mf or DC in contact with another host cell, it is also found in neural tissues where it may be involved in regulating migration of nerve cells, formation of cell protrusions, and Summary of SIRPA (BIT, CD172a, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2) expression in human tissue. Cytoplasmic expression CD47 is a molecule that is highly expressed on the surface of many tumors, where it acts as a myeloid-specific immune checkpoint. By binding to SIRPa, an inhibitory receptor on macrophages and other myeloid cells, CD47 is able to transduce inhibitory signals that prevent macrophage phagocytosis. 2020-08-18 · We show that CD47-SIRPA prevents integrin activation, allowing macrophages to quickly discriminate between targets based on the presence of CD47.